Saturday, May 06, 2006

Studies Find Elusive Key to Cell Fate in Embryo -- NY Times

Some recent Cell papers referenced in the NY Times that seem to imply that "master regulator" TFs are themselves regulated by specific chomatin modifications. 

Studies Find Elusive Key to Cell Fate in Embryo
Published: April 25, 2006
For three billion years, life on earth consisted of single-celled organisms like bacteria or algae. Only 600 million years ago did evolution hit on a system for making multicellular organisms like animals and plants.

Cell. 2006 Apr 21;125(2):315-26. 
A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES.

Cell. 2006 Apr 21;125(2):301-13.   
Control of developmental regulators by polycomb in human embryonic stem cells.
Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K, Odom DT, Otte AP, Volkert TL, Bartel DP, Melton DA, Gifford DK, Jaenisch R, Young RA.

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