Showing posts with label compilationsummary. Show all posts
Showing posts with label compilationsummary. Show all posts

Wednesday, August 07, 2013

Remarks on a Collection of Security Now Podcasts Giving an Overview of Computing Fundamentals

Security Now episodes 233, 235, 237, 239 and 241 give a nice overview of the fundamentals of computing. In particular, they form an inter-linked collection of podcasts that go over computing starting at simple execution of a program utilizing a program counter through discussing indirection, stacks, recursion and, finally, interrupts. Each of the episodes builds upon the previous and covers many of the key points very lucidly. I would recommend them to people who want to get a quick overview of some of the elements of computing purely by listening to audio.

Security Now 233 - The Official TWiT Wiki
[[*good episode that starts w. transistors logic for not and nor and
goes through mem. as 2 Nors and then ICs. Episode 235 continues. *]]

Security Now 235 - The Official TWiT Wiki

Security Now 237 - The Official TWiT Wiki

Security Now 239 - The Official TWiT Wiki
Stacks, Registers, and Recursion
http://twit.tv/show/security-now/239

Security Now 241
Hardware Interrupts
http://twit.tv/show/security-now/241

[tags twit.tv clip, clippodcast, pubsecuritynow, 0dx90817podq, itunes0mg, pod57]

Saturday, June 29, 2013

Worries about a Genomic PRISM + a Collection of Privacy Related Material (Previously Posted)

The recent news focus on Edward Snowden and the NSA's PRISM program has shed a bright spotlight on privacy and how it relates to large-scale data mining. One interesting angle related to this is connecting privacy worries related to PRISM with the new government initiatives to create a huge database of genomic information. I'm quite interested in this and genomic privacy in general. Below I've collected some relevant links and related previous posts.

More practically, the issue of genomic privacy is crucial for a small lab working in bioinformatics. Basically, because of privacy concerns, the ecosystem of medical and genomic data is going to change considerably in the future -- becoming both larger but also more locked-down -- and consequently, it'll have to rely more on robust intra-institutional collaborations than large public databases .


* Recent USA Today op-ed by Dov Greenbaum & myself on this topic



* Selection of  my previous opeds & letters to the editor on genomic privacy 



Even more at:


* Some academic papers I have written about privacy



* NCI Workshop on Genomic Privacy



* Recent piece in the NY Times related to genomic privacy 


"Poking Holes in Genetic Privacy,"


* Amusing Atlantic article on hacking the president's genome


I thought this was a good counterpoint to PRISM
Here's my unpublished letter in response to this:

Friday, April 19, 2013

Some "oldies but goodies"

Recently I was going through lots of my old xeroxed articles and thought I'd make a reference collection of some "oldies but goodies" – classic research articles that I liked. Here we go....

Genomics

Common sense for our genomes.
Brenner SE.
(*)

SNP detection and genotyping from low-coverage sequencing data on multiple diploid samples.
Le SQ, Durbin R.
(*)

Prostate cancer genomics: towards a new understanding.
Witte JS.
(*)

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.
Shah SP, Morin RD, Khattra J, Prentice L, Pugh T, Burleigh A, Delaney A, Gelmon K, Guliany R, Senz J, Steidl C, Holt RA, Jones S, Sun M, Leung G, Moore R, Severson T, Taylor GA, Teschendorff AE, Tse K, Turashvili G, Varhol R, Warren RL, Watson P, Zhao Y, Caldas C,Huntsman D, Hirst M, Marra MA, Aparicio S.
(*)

Repeatability of published microarray gene expression analyses.
Ioannidis JP, Allison DB, Ball CA, Coulibaly I, Cui X, Culhane AC, Falchi M, Furlanello C, Game L, Jurman G, Mangion J, Mehta T,Nitzberg M, Page GP, Petretto E, van Noort V.
(*)

Genome re-annotation: a wiki solution?
Salzberg SL.
(*)

Mining and Statistical Genetics

Mapping complex disease traits with global gene expression.
Cookson W, Liang L, Abecasis G, Moffatt M, Lathrop M.
(*)

Genetic mapping in human disease.
Altshuler D, Daly MJ, Lander ES.
(*)

The genetic basis for cancer treatment decisions.
Dancey JE, Bedard PL, Onetto N, Hudson TJ.
(*)

Bayesian statistical methods for genetic association studies.
Stephens M, Balding DJ.
(*)

Gene set enrichment analysis made simple.
Irizarry RA, Wang C, Zhou Y, Speed TP.
(*)

Genomewide association studies--illuminating biologic pathways.
Hirschhorn JN.
(*)

Detecting gene-gene interactions that underlie human diseases.
Cordell HJ.
(*)

Equilibrium free energies from nonequilibrium measurements using maximum-likelihood methods.
Shirts MR, Bair E, Hooker G, Pande VS.
(*)

On the use of DNA pooling to estimate haplotype frequencies.
Wang S, Kidd KK, Zhao H.
(*)

Beyond odds ratios--communicating disease risk based on genetic profiles.
Kraft P, Wacholder S, Cornelis MC, Hu FB, Hayes RB, Thomas G, Hoover R, Hunter DJ, Chanock S.
(*)

Networks

Complex brain networks: graph theoretical analysis of structural and functional systems.
Bullmore E, Sporns O.
(*)

Evolvability and hierarchy in rewired bacterial gene networks.
Isalan M, Lemerle C, Michalodimitrakis K, Horn C, Beltrao P, Raineri E, Garriga-Canut M, Serrano L.
(*)

Systems biology. Attractors and democratic dynamics.
Bar-Yam Y, Harmon D, de Bivort B.

(*)

New surveyor tools for charting microbial metabolic maps.
Breitling R, Vitkup D, Barrett MP.
(*)

Misc

Pharmacogenomics arrives.
Petsko GA.
(*)

Use and misuse of the gene ontology annotations.
Rhee SY, Wood V, Dolinski K, Draghici S.
(*)

The discovery of structural form.
Kemp C, Tenenbaum JB.
(*)

The language of genes.
Searls DB.
(*)

Genetics of athletic performance.
Ostrander EA, Huson HJ, Ostrander GK.
(*)

Graduate education in the biomedical sciences: critical observations on training for research careers.
Kennedy TJ Jr.
(*)

Creation of a bacterial cell controlled by a chemically synthesized genome.
(*)

Diet and health: what should we eat?
Willett WC.
(*)

Organization, development and function of complex brain networks.
Sporns O, Chialvo DR, Kaiser M, Hilgetag CC.
(*)

Music theory. Geometrical music theory.
Hall RW.
(*)

Social science. Computational social science.
Lazer D, Pentland A, Adamic L, Aral S, Barabasi AL, Brewer D, Christakis N, Contractor N, Fowler J, Gutmann M, Jebara T, King G,Macy M, Roy D, Van Alstyne M.
(*)

Interpreting anonymous DNA samples from mass disasters--probabilistic forensic inference using genetic markers.
Lin TH, Myers EW, Xing EP.
(*)

A diagnostic approach for going beyond panaceas.
Ostrom E.
(*)

Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling.
Ferrara CT, Wang P, Neto EC, Stevens RD, Bain JR, Wenner BR, Ilkayeva OR, Keller MP, Blasiole DA, Kendziorski C, Yandell BS,Newgard CB, Attie AD.
(*)

The scientific research potential of virtual worlds.
Bainbridge WS.
(*)

New models of collaboration in genome-wide association studies: the Genetic Association Information Network.
(*)

Saturday, May 07, 2011

Some interesting things in Science & Nature from 18 Nov. '10 to 11 Feb. '11

Here's some things I found interesting from Science & Nature (and their podcasts) from 18 Nov. '10 to 11 Feb. '11.

Science

* A survey of microbiomes in different organisms shows that
phylogenetic relatedness trumps environment and diet in terms of
predicting the similarity of gut microbes (3 Dec.)

* Denoeud et al. "Plasticity of Animal Genome Architecture Unmasked by Rapid Evolution of a Pelagic Tunicate" (3 Dec., http://www.sciencemag.org/content/330/6009/1381.full). Quoting: "Two distinct haplotypes were retained, despite inbreeding."

* In Dec. 10 Science, there's an interesting paper related to yo-yo dieting, showing that mice on such a diet have high levels of cortisol, a stress hormone ("Thought for Food: Imagined Consumption Reduces Actual Consumption").

* Interesting story in 10 Dec. Science about using sensitive DNA
sequencing -- to identify fish populations and to analyze fetal DNA
directly from blood ("To Fight Illegal Fishing, Forensic DNA Gets Local").

* In 28 Jan. Science there's an interesting discussion of an infective cancer in dogs and
differences found in clustering the dog breeds vs the cancers.

* The water flea genome has lots of duplications, which appear to diverge quickly in terms of gene expression (Colbourne et al. "The Ecoresponsive Genome of Daphnia pulex,"4 Feb.).

* 11 Feb. Science was the "Data Issue," which contained a good lead article on personal genomics and ethics of consent (Couzin-Frankel, "What Would You Do?"). Another article on scaling of data was also very interesting (Martin Hilbert & Priscila López, "The World’s Technological Capacity to Store, Communicate, and Compute Information," 1 Apr.).

Nature & misc.

* An interesting paper on dev. biology: Kalinka et al. "Gene expression divergence recapitulates the developmental hourglass model," Nature 468: 811

* Great article illustrating the bias in the selection of protein sets chosen -- in contrast to the situation for genes!
Edwards et al. "Too many roads not taken," Nature (13 Feb.)
http://www.nature.com/nature/journal/v470/n7333/full/470163a.html

* Here's an interesting article in Curr. Biology where
the authors developed a way to determine the age of a human DNA sample via
analyzing a particular section of DNA excised in T-cells. There's less and less as we get older.
http://promega.wordpress.com/2010/12/17/analyzing-dna-to-determine-a-person%E2%80%99s-age/
http://www.ncbi.nlm.nih.gov/pubmed/21093786

[[* Scinatpodfeb11 *]]